secobarbital will lower the extent or effect of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Potent or moderate CYP3A4 inducers may well improve rate of diazepam elimination; therefore, efficacy of diazepam may very well be diminished.secobarbital will minimize the extent or effect of budesonide… Read More